Strongest Bed Bug Killer Sprays: {7 Sprays Tried & Tested}

No, you don’t have to get rid of your mattress if you have a bed bug infestation. This is, in fact, strongly discouraged. Disposing bed bug-infested objects can seem irresponsible, as it may lead to the spread of the infestation.

One of the most effective solutions for killing bed bugs instantly is by using a bed bug spray.

Here, we will introduce you to the strongest bed bug killer spray you can easily avail in the market to get rid of annoying bed bugs.

Strongest Bed Bug Killer We Tried

The bed bug killer sprays we tried are

1. Ortho Home Defense Max Bed Bug

Being crowned as one of the best bed bug spray, the Ortho Home Defense Max Bed Bug stand with it.

Although bed bugs are difficult to get rid of due to their speedy reproduction rates and their small flat bodies that make them adept at squeezing through small spaces. To successfully eradicate an infestation, you need to use a string bed bug spray and the Ortho Home Defense Max Bed Bug gets the cue to get itself in action.

On contact, the 1.5 gallons of quick-acting solution can easily eliminate bed bugs. It also kills the larvae, so you can spray it directly on the bugs’ nests or into crevices and cracks where they may be hiding.

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You can use it as a spot treatment around bed frames, mattress seams, tufts, folds, and baseboards to eliminate the bed bugs you see and the places where they hide to control the infestation. In addition, it eliminates fleas and ticks in your house.

Another thing why this is one of the best bed bug killers is that it is safe to use around kids and pets when used as directed. It dries easily – within a couple of hours at most. And it is safe for pets after 6-8 hours, but it must be fully dry before then.

The Ortho Home Defense Max Bed Bug is also formulated to have a minimum shelf life of 3 years when properly stored, but will often last longer so you do not have to worry about buying multiple times.

  • Safe for children and pets
  • Long shelf life
  • Fast acting formula
  • Fast drying
  • Low odor
  • Comfort wand may not be included
  • May not work on some instances

2. Eco Defense Bed Bug Spray

The Eco Defense Bed Bug Spray is one of the best bed bug killer out there.

Not just it kills bed bugs in contact, but it is made of natural, organic, and non-toxic ingredients to help eliminate bed bugs in all stages of life; form eggs, nymphs, and adults. You do not have to worry much about fumes or dangerous pesticides and chemicals coming in contact with you and your family and pets.

The Eco Defense Bed Bug Spray also has a non-staining formula so it assures you that it won’t stain your bedding like some products on the market. Just apply it directly to sheets, mattress and cover to kill bed bugs on site.

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Eco Defense Bed Bug Killer Spray is effective and simple to use. Many customers have considered it to be more user-friendly and effective than other bed bug items such as powders, traps, and foggers. Eco Defense is, without a doubt, one of your best choice when it comes to the best bed bug sprays you can get.

Finally, it is assured to perform well because it is formulated by professional exterminators. It also offers a money back guarantee with a 60-day trial period and if you are not satisfied with the results, they will refund your money 100% with no questions asked.

  • Low odor
  • Organic formula
  • Safe for children and pets
  • Money back guarantee
  • Non-staining
  • Can cause burning on sensitive skin
  • Too long to process money back

3. HARRIS Bed Bug Killer

Harris is the oldest EPA-registered corporation in the United States. The company offers more than 100 items to treat everything from roaches and bed bugs to scorpions and stink bugs. Harris uses informative labeling, instructional videos, and personal guidance to help consumers find simple and cost-effective pest-control solutions.

Being named as one of the toughest liquid bed bug spray with odorless and non-staining formula, the HARRIS Bed Bug Killer is literary one of the best bed bug killers you can get.

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It eliminates even the most resistant pyrethroid-resistant bed bugs and eggs that have developed resistance to other pesticides. Apply as a spot treatment to cracks and crevices or harborages, where evidence of bed bugs occurs, including bed frames, box springs, inside empty dressers, furniture and clothes, closets, carpet edges, high and low wall moldings, behind headboards, pictures, wallpaper edges and luggage. When sprayed directly on bed bugs, it kills them quickly.

Another good thing about this product is that it is approved for use in homes with people and pets by the Environmental Protection Agency.

The HARRIS Bed Bug Killer continues to kill bed bugs for up to 16 weeks after initial application because of its long-residual formulation. The odorless and non-staining formula will not cause damage to fabrics when used according to label directions.

  • Easy to apply
  • Odorless
  • Fast acting formula
  • EPA approves
  • Bad delivery packaging
  • Can be harmful to sensitive people

4. JT Eaton Oil Based Bedbug Spray

There are no miracle sprays that effectively destroy bed bugs. When applied carefully and directly to bed bugs and their hiding places, most commercial insecticides can kill them.

The JT Eaton Oil-based bed bug spray is another great thing to consider when buying the best bed bug killers.

JT Eaton kills bedbugs and crawling insects and is safe to use around people and pets as directed on the product label. Just keep in mind that pets and people should be kept out of the treatment area during treatment and until the spray formula has settled.

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It comes with ready-to-use sprayer attachments to kill bed bugs, fleas, brown dog ticks and other insects. Simply spray on the infected area and the bedbugs will begin to die off. The active ingredients are Pyrethrin (0.13-percent) and Piperonyl Butoxide (1.27-percent) which effectively kills bedbugs and other insects without leaving residuals.

This is a great spray for killing bed bugs and their eggs. It is easy to used and won the bed bug battle. It is one of the sprays on the market that lasts for approximately 12 weeks and it can be used as an addition to other products to kill bed bugs. If you have a bad bed bug infestation, you will need to use several products but the JT Eaton Oil Based Bedbug Spray is a top choice to get.

  • Oil-based
  • Active killing ingredients
  • 1-year limited warranty
  • Comes in a spray bottle
  • Safe for kids and pets
  • May not work all the time
  • May leave oil residues

5. Bed Bug Killer by EcoRaider

This is one of the best bed bug sprays you can get and it actually works really well however, it wasn’t that easy. You can’t just spray magic spray and do bed bug dances during a full moon and expect them to keel over dead.

EcoRaider Bed Bug Spray contains many botanical-based ingredients that act to paralyze and destroy bed bugs, including cedarwood. Anyone may use this spray to stop a bed bug infestation in its tracks or prevent one from developing. It is also certified by the USDA BioBased insecticide, dermatologically safe for anyone near it.

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The Bed Bug Killer by EcoRaider offers great performance when it comes to bed bugs. When sprayed directly on bed bugs in two trials, these products were the only ones that provided greater than 90% control of bed bug nymphs. EcoRaider™ caused 100 percent mortality after 10 days in two trials. Bed Bug Patrol™ caused 91-92 percent mortality after 10 days in two trials.

Although the EcoRaider Bed Bug Spray may appear to be pricey to some, the ingredients have been shown to be safe and effective for at-home care. If you’ve seen bed bugs in your home or want to take preventative steps, this product is a great option.

  • Natural ingredients
  • USDA certified
  • High mortality rate
  • Comes in spray bottles
  • No residues
  • Can last a bit shorter than other products
  • Has a strong smell

6. Premo Guard Bed Bug & Mite Spray

The Premo Guard Bed Bug & Mite Spray is made with all-natural ingredients that work. It’s perfectly safe to use around family, pets, and plants.

A natural insecticide developed by team of entomologists. Without having to think about bed bugs or mites, you will get a decent night’s sleep. Bedding and pillows will not be stained. Just apply to sheets, mattresses, and pillowcases directly. There is no odor, and there are no toxic fumes from conventional pesticides.

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Designed specifically for pest control in both the home and the workplace. Bed bugs, dust mites, scabies itch mites, spider mites, bird mites, asesino de chinches, los acaros, stink bugs, cockroaches, silverfish, fleas, and ants have all been field checked and shown to be eliminated. The formula works by burning the outer shell of the bug, causing immediate kill on contact.

For small and medium infestations, it is truly successful. Adults and nymphs are killed on contact, and eggs are destroyed. And pesticide-resistant bugs are killed. This product is guaranteed to come from facilities that are Certified Natural Products Association (NPA) and Authorized Good Manufacturing Practice (GMP) certified. All of the items have been thoroughly reviewed and certified by a third party.

  • NPA and GMP approved
  • Safe for all
  • Odorless
  • Good shelf life
  • Spray bottle packaging
  • A little bit pricey
  • Sometimes fail to kill bugs

7. Raid Max Bed Bug Extended Protection

The Raid Max Bed Bug Extended Protection stands to its name. It offers long lasting protection because of its amazing formula.

This spray is intended to destroy both bed bugs and their larvae. It helps to kill the whole population, allowing you to keep your company or home pest-free. The wide range of activities ensures maximum bug eradication and prevents re-infestation. As a result, it is the most effective insecticide available. The tool comes in a jar with an extender wand that makes it simple to reach the bugs hiding in deep cracks and crevices.

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It kills bed bugs and their eggs on contact and keeps them out of your mattress for up to 8 weeks. The Raid Max Bed Bug Extended Protection is tough and easy to use, when all you have to do is spray the solution on laminated wood and other surfaces to combat Pyrethroid resistant bed bug strains.

Raid bed bug spray may be used as a spot solution or a whole-house use. As a surface mist, you can spread the substance over a wide area. So, based on what it offers, the Raid Max Bed Bug Extended Protection is exceptional and can be among the best bed bug sprays you can avail in the market today without any hesitation.

  • Fast action
  • Great formulation
  • Long lasting effect
  • Kills both larvae and adult
  • Strong smell
  • Can miss some bugs

How to Use a Bed Bug Spray

Bedbugs are just 5 millimeters long, around the size of a pencil eraser. These bugs are intelligent, hardy, and prolific.

Fortunately, bedbugs can be eradicated. Just be patient, as bedbug removal can take a long time and effort. If you have a major infestation, you can need to pursue a few different chemical approaches such as bed bug sprays.

Here’s a step-by-step procedure on how to use it.

Step 1 : Clear The Area

Remove all personal things, such as stuffed animals, soft toys, curtains, appliances, and everything else that will not be permanently in the room.

Step 2 : Dismantle Bed Frame 

Dismantle bed frames in infested areas typically expose bed bug hiding sites. Having access to these areas during cleaning is important.

Step 3 : Spray Area

Spray around and under the bed, as well as around the bed’s baseboards. The interior of the cabinetry, as well as the bottom and sides of the drawers, should be sprayed after the drawers have been removed from the furniture. The insides of the drawers should not be handled. The clothes in the drawers should be removed and laundered if necessary. Also look for them in places like these: near the tags of the mattress and box spring, in cracks in the bed frame and headboard, in baseboards, between couch cushions, in furniture joints, inside electrical outlets, under loose wallpaper, underneath paintings and posters on the walls, in the seam where the wallpaper and ceiling meet.

Step 4 : Wait

Wait for the bed bug spray to set. Typically, it takes about 30 minutes to 2 hours per room depending on size and condition of the room.

Step 5 : Clean

Clean all the dead bed bugs and return all your things to place. Repeat the procedures if re-infestation occurs.


Bedbugs are tough insects. You could see them again just when you think you’ve gotten rid of them. To get rid of the infestation, you may have to try a few different treatments such as trying a bed bug spray.

I hope that this article helped you get rid of those annoying creepy crawlies that keeps you from getting a good night sleep.

Dinesh Kumar

Hello, I'm Dinesh. I have 4 years of experience in dealing with pests. I try to provide you the best information that'll help you to make the pest control process easy & affordable. In recent years, I've helped hundreds of homeowners to protect their home from pests like bed bugs, cockroaches, fleas, house flies, snakes, rats and other pests.

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